The old Schilling test as a necessary criterion at present for the diagnosis of food-cobalmin malabsorption (FCM) syndrome.

www.nuclmed.gr 262 September December 2012 intake of proton pump inhibitors, H2-receptor antagonists, or metformin. In a number of recently published series, especially in elderly patients, FCM syndrome appears to be the leading cause of various Cbl deficiency aetiologies accounting for about 50%-60% of the cases, while pernicious anaemia (PA) is accounts for about 15%-30% of the cases. It should be noted that for measuring Cbl, various methods have been used: (chemiluminescence or radioassay) and consequentThe inability to release vitamin B12 (Cbl) from its carrier proteins is characterized as food-cobalamin malabsorption (FCM) syndrome, the leading cause of Cbl deficiency in the elderly. This syndrome was first described by Doscherholmen in 1973 and well characterized by Carmel and Dawson in the 1990s. Several causes or “associated” disorders of Cbl malabsorption have been reported, the most common being age, atrophic gastritis, gastric disease associated with Helicobacter pylori infection, and the The old Schilling test as a necessary criterion at present for the diagnosis of food-cobalamin malabsorption (FCM) syndrome